Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling
Lianbi Zhao, Tian Zhou, Jianmei Chen, Wenbin Cai, Ruijing Shi, Yunyou Duan, Lijun Yuan, Changyang Xing
Abstract
abundance in the intestine when endocytosed. Oral delivery of miR-155 antagonist restored the protective microbiota and thus protected the cardiac function in the OVX mice. This study has established a possible regulatory axis of intestinal miRNAs-microbiota-estrogen deficiency related phenotype in the OVX model. Colon specific delivery of therapeutic miRNAs would possibly restore the microbiota toward protective phenotype in the context of metabolic syndrome.
Topics & Concepts
Context (archaeology)EstrogenOvariectomized ratGut floraBiologyEndocrinologyInternal medicineCardiac function curveAdipose tissueMedicineImmunologyHeart failurePaleontologyGut microbiota and healthHelicobacter pylori-related gastroenterology studiesIL-33, ST2, and ILC Pathways