Interplay between Hypoxia and Extracellular Vesicles in Cancer and Inflammation
Marta Venturella, Mattia Criscuoli, Fabio Carraro, Antonella Naldini, Davide Zocco
Abstract
Hypoxia is a severe stress condition often observed in cancer and chronically inflamed cells and tissues. Extracellular vesicles play pivotal roles in these pathological processes and carry biomolecules that can be detected in many biofluids and may be exploited for diagnostic purposes. Several studies report the effects of hypoxia on extracellular vesicles' release, molecular content, and biological functions in disease. This review summarizes the most recent findings in this field, highlighting the areas that warrant further investigation.
Topics & Concepts
BiologyExtracellular vesiclesInflammationHypoxia (environmental)ExtracellularVesicleExtracellular vesicleCell biologyBiochemistryImmunologyMicrovesiclesGenemicroRNAOxygenMembraneOrganic chemistryChemistryExtracellular vesicles in diseaseMicroRNA in disease regulationCardiovascular Disease and Adiposity