Acinetobacter baumannii Targets Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules (CEACAMs) for Invasion of Pneumocytes
Cecilia Ambrosi, Daniela Scribano, Meysam Sarshar, Carlo Zagaglia, Bernhard B. Singer, Anna Teresa Palamara
Abstract
This work shows for the first time that Acinetobacter baumannii binds to carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM5, and CEACAM6. This binding significantly enhances A. baumannii internalization within alveolar host cell epithelia.
Topics & Concepts
Acinetobacter baumanniiCarcinoembryonic antigenInternalizationCell adhesion moleculeMicrobiologyCell adhesionAdhesionCellChemistryBiologyBacteriaCell biologyBiochemistryCancerPseudomonas aeruginosaGeneticsOrganic chemistryAntibiotic Resistance in BacteriaInhalation and Respiratory Drug DeliveryPneumonia and Respiratory Infections