A chimeric hairpin DNA aptamer-based biosensor for monitoring the therapeutic drug bevacizumab
Shengfeng Huang, Mengyun Zhang, Feng Chen, Huihui Wu, Minyi Li, Jacques Crommen, Qiqin Wang, Zhengjin Jiang
Abstract
) with a wide linear range (1 pM-1 μM) was obtained. Finally, the rationally constructed biosensor was successfully applied to the determination of bevacizumab in spiked samples, and it showed good accuracy and precision. This method is expected to truly realize accurate and rapid detection of bevacizumab and provides a new idea for the precise treatment of diseases.
Topics & Concepts
AptamerMicroscale thermophoresisBiosensorDetection limitChemistryBevacizumabDNAChromatographyLinear rangeNanotechnologyCombinatorial chemistryMaterials scienceMolecular biologyBiologyBiochemistryChemotherapyGeneticsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionMolecular Junctions and Nanostructures