Screening of dual targeted inhibitors of 5-lipoxygenase and cyclooxygenase-2 from Oroxylum indicum by off-line two-dimensional liquid chromatography coupled with mass spectrometry
Xin-jie Cheng, Dezhi Kong, Yahui Li, Guang-li Bian, Deqiang Li
Topics & Concepts
ChemistryBaicaleinArachidonate 5-lipoxygenaseEnzymeLipoxygenaseCyclooxygenaseChromatographyIC50ChrysinDocking (animal)Mass spectrometryIn vitroBiochemistryPharmacologyFlavonoidArachidonic acidAntioxidantBiologyMedicineNursingNatural product bioactivities and synthesisInflammatory mediators and NSAID effectsPhytochemistry and Biological Activities