Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma
Annabell Bachem, Michele V. Clarke, Geraldine Kong, Ilaryia Tarasova, Lachlan Dryburgh, Lindsay Kosack, Ariane R. Lee, L. G. M. Newland, Teagan Wagner, Emma Bawden, Kah Min Yap, Michael D. Wilson, Sven Engel, Kayla R. Wilson, Brendan E. Russ, Kshitij Tandon, Peter K. H. Lau, Grant A. McArthur, Vanessa R. Marcelino, Paul A. Beavis, Stephen J. Turner, Jason Waithman, Timothy P. Stinear, Shahneen Sandhu, Jan Schröder, Thomas Gebhardt, Sammy Bedoui
Topics & Concepts
ButyrateBiologyMelanomaImmunityGut floraCancer researchImmune systemBlockadeT cellImmune checkpointImmunologyButyric acidImmunotherapyMicrobiologyPhenotypic switchingSuperantigenCell biologyCancerMetaboliteMetabolic pathwayLymph nodeFlux (metallurgy)CellMicrobiomeTumor microenvironmentCancer Immunotherapy and BiomarkersImmune cells in cancerGut microbiota and health