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Improved therapeutic efficacy in two mouse models of methylmalonic acidemia (MMA) using a second-generation mRNA therapy

Kimberly A. Coughlan, Marianne Eybye, Nicholas Henderson, Christine DeAntonis, Andrea Frassetto, Erin Hanahoe, Tatiana Ketova, Eric Jacquinet, Vladimir Presnyak, Ruchi Jain, John Marshall, Paolo G.V. Martini

2024Molecular Genetics and Metabolism18 citationsDOI

Topics & Concepts

Methylmalonic acidemiaMethylmalonic acidMedicineChemistryInternal medicineHomocysteineMetabolism and Genetic DisordersMitochondrial Function and PathologyPeroxisome Proliferator-Activated Receptors
Improved therapeutic efficacy in two mouse models of methylmalonic acidemia (MMA) using a second-generation mRNA therapy | Litcius