A strategic Ser/Cys exchange in the catalytic triad unlocks an acyltransferase-mediated synthesis of thioesters and tertiary amides
Martina Letizia Contente, David Roura Padrosa, Francesco Molinari, Francesca Paradisi
Topics & Concepts
BiocatalysisChemistryCatalytic triadAcyltransferaseThioesterCatalysisAcyltransferasesSubstrate (aquarium)Combinatorial chemistryOrganic synthesisCofactorOrganic chemistryEnzymeStereochemistrySerineBiosynthesisReaction mechanismBiologyEcologyChemical Synthesis and AnalysisMicrobial Natural Products and BiosynthesisBiochemical and Molecular Research