Olefin Hydroarylation Catalyzed by a Single-Component Cobalt(-I) Complex
Benjamin A. Suslick, T. Don Tilley
Abstract
A single-component Co(-I) catalyst, [(PPh3)3Co(N2)]Li(THF)3, has been developed for olefin hydroarylations with (N-aryl)aryl imine substrates. More than 40 examples were examined under mild reaction conditions to afford the desired alkyl-arene product in good to excellent yields. Catalysis occurs in a regioselective manner to afford exclusively branched products with styrene-derived substrates or linear products for aliphatic olefins. Electron-withdrawing functional groups (e.g., -F, -CF3, and -CO2Me) were tolerated under the reaction conditions.
Topics & Concepts
ChemistryOlefin fiberCatalysisRegioselectivityArylStyreneAlkylImineCobaltComponent (thermodynamics)Medicinal chemistryOrganic chemistryCopolymerThermodynamicsPhysicsPolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCarbon dioxide utilization in catalysis