Silica-Coated Magnetic Nanoparticles for Vancomycin Conjugation
Moustafa M. Abdelaziz, Amr Hefnawy, Asem Anter, Menna M. Abdellatif, Mahmoud A. F. Khalil, Islam A. Khalil
Abstract
of 183.43 μg/mL, compared to a much lower value of 54.11 μg/mL for free vancomycin. While the antibacterial studies showed a comparable activity of the developed formulation, the minimum inhibitory concentration was 25 μg/mL, compared to 20 μg/mL for free vancomycin. Accordingly, the reported formulation can be used as a platform for the targeted and efficient delivery of other drugs.
Topics & Concepts
NanoparticleConjugated systemMagnetic nanoparticlesVancomycinBiocompatibilityMaterials scienceCoatingNanotechnologyChemistryBacteriaOrganic chemistryPolymerStaphylococcus aureusGeneticsBiologyAntimicrobial Peptides and ActivitiesBacteriophages and microbial interactionsAntibiotic Resistance in Bacteria