Visible‐Light‐Promoted Metal‐Free C‐H Trifluoromethylation of Imidazopyridines
Xia Mi, Yuanfang Kong, Huaixia Yang, Jingyu Zhang, Chao Pi, Xiuling Cui
Abstract
A metal‐free photo redox C–H trifluorometlylation of imidazopyridines is described. The reaction is operationally simple and the easy‐handling CF 3 SO 2 Na serves as an effective fluoroalkyl radical precursor. Various functional groups were tolerated under blue LED light to access the desired products in satisfied yields at room temperature.
Topics & Concepts
TrifluoromethylationChemistryVisible spectrumRedoxMetalPhotochemistryCombinatorial chemistryOrganic chemistryOptoelectronicsPhysicsTrifluoromethylAlkylFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions