Chirality sensing of terpenes, steroids, amino acids, peptides and drugs with acyclic cucurbit[<i>n</i>]urils and molecular tweezers
Amrutha Prabodh, Daniel J. Bauer, Stefan Kubik, Philipp Rebmann, Frank Gerritt Klärner, Thomas Schräder, Lorenzo Delarue Bizzini, Marcel Mayor, Frank Biedermann
Abstract
Achiral chromophoric hosts, i.e. acyclic cucurbit[n]urils and molecular tweezers, were found to respond with characteristic Circular Dichroism (CD) spectra to the presence of micromolar concentrations of chiral hydrocarbons, terpenes, steroids, amino acids and their derivates, and drugs in water. In favourable cases, this allows for analyte identification or for reaction monitoring.
Topics & Concepts
TerpeneChirality (physics)Circular dichroismChemistryAmino acidStereochemistryMolecular tweezersTweezersOrganic chemistryCombinatorial chemistryMoleculeBiochemistrySupramolecular chemistryChiral symmetryPhysicsQuantum mechanicsPhysical chemistryQuarkNambu–Jona-Lasinio modelMolecular spectroscopy and chiralityMolecular Sensors and Ion DetectionAnalytical Chemistry and Chromatography