<i>In Vitro</i> Activity of the Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas aeruginosa
Olga Lomovskaya, Debora Rubio-Aparicio, Kirk Nelson, Dongxu Sun, Ruslan Tsivkovski, Mariana Castanheira, Jill Lindley, Jeffery S. Loutit, Michael Dudley
Abstract
QPX7728 is an ultra-broad-spectrum beta-lactamase inhibitor with potent inhibition of key serine and metallo beta-lactamases. QPX7728 enhances the potency of multiple beta-lactams in beta-lactamase-producing Enterobacterales and Acinetobacter spp.
Topics & Concepts
Pseudomonas aeruginosaBeta-lactamAntibioticsBETA (programming language)MicrobiologyBeta-lactamaseBeta-Lactamase InhibitorsAcinetobacterIn vitroBiologyChemistryBacteriaEscherichia coliBiochemistryGeneticsGeneComputer scienceProgramming languageAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingPharmaceutical and Antibiotic Environmental Impacts