3D bioprinting of a gradient stiffened gelatin–alginate hydrogel with adipose-derived stem cells for full-thickness skin regeneration
Yuan Ma, Yilin Wang, Danni Chen, Ting Su, Qiang Chang, Wenhua Huang, Feng Lu
Abstract
the animal wound model and was mainly attributed to the enhanced paracrine secretion of adipose-derived stem cells by the physical microenvironment provided within the gradient stiffness scaffold. The current 3D printed gradient scaffolds provide adipose-derived stem cells with a distinct yet successive architecture rather than the typical uniform microenvironment to accelerate skin regeneration, which may have broader applications in other chronic wounds or tissue defects.
Topics & Concepts
Self-healing hydrogelsAdipose tissueGelatinScaffoldRegeneration (biology)Paracrine signalling3D bioprintingMaterials scienceStem cellBiomedical engineeringCell biologyTissue engineeringChemistryBiologyMedicineReceptorBiochemistryPolymer chemistry3D Printing in Biomedical ResearchWound Healing and TreatmentsPlanarian Biology and Electrostimulation