Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors
Haochao Zhang, Liandong Jing, Man Liu, Masuo Goto, Fangfang Lai, Xiao Liu, Sheng Li, Yajun Yang, Ying Yang, Yan Li, Xiaoguang Chen, Kuo‐Hsiung Lee, Zhiyan Xiao
Topics & Concepts
ChemistryCyclin-dependent kinase 8KinaseCyclin-dependent kinaseIC50Lead compoundStereochemistryBiochemistryIn vitroCell cycleSignal transductionCellNotch signaling pathwayCancer-related Molecular PathwaysAdvanced Breast Cancer TherapiesCancer Mechanisms and Therapy