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Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease

Li-Kung Wu, Surbhi Agarwal, Chia‐Hua Kuo, Yen‐Lun Kung, Cecilia Hsuan Day, Pi‐Yu Lin, Shinn‐Zong Lin, Dennis Jine‐Yuan Hsieh, Chih‐Yang Huang, Chien-Yi Chiang

2022Phytomedicine81 citationsDOI

Topics & Concepts

Substantia nigraNeuroprotectionPars compactaAutophagyMPTPPharmacologyMitophagyViability assayParkinson's diseasePI3K/AKT/mTOR pathwayNeurotoxicityDopaminergicBiologyChemistryCell biologyMedicineDopamineBiochemistryNeurosciencePathologySignal transductionInternal medicineToxicityIn vitroApoptosisDiseaseCalcium signaling and nucleotide metabolismAutophagy in Disease and TherapySirtuins and Resveratrol in Medicine
Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease | Litcius