The pharmacology of the TMEM16A channel: therapeutic opportunities
Rumaitha Al‐Hosni, Zeki Ilkan, Emilio Agostinelli, Paolo Tammaro
Abstract
channel is involved in a variety of vital physiological functions and may be targeted pharmacologically for therapeutic benefit in diseases such as hypertension, stroke, and cystic fibrosis (CF). The determination of the TMEM16A structure and high-throughput screening efforts, alongside ex vivo and in vivo animal studies and clinical investigations, are hastening our understanding of the physiology and pharmacology of this channel. Here, we offer a critical analysis of recent developments in TMEM16A pharmacology and reflect on the therapeutic opportunities provided by this target.
Topics & Concepts
Clinical pharmacologyPharmacologyPsychologyMedicineNeuroscienceIon channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias