Antioxidant Activity of Thiosulfonate Compounds in Experiments in Vitro and in Vivo
Liubas Nataliia, Iskra Ruslana, Nataliya Stadnytska, N. Ya. Monka, Havryliak Viktoriia, Lubenets Vira, David Da, Silva, Carlos Stuepp, Ivar Wendling, Cristiane Vieira Helm, Alessandro Angelo, T Javed, I Afzal, Y Qiu, M Amirkhani, H Mayton, Z Chen, A Taylor, J Zinsmeister, O Leprince, J Buitink, Filippo Guzzon, Gianella, ; Maraeva, Jose Juarez, Alejandro Velazquez, ; Cano, Cesar Sanchez, ; E Costich, Denise, Damini Kothari, Woo-Do Lee, Soo-Ki Kim, Antonio Sorlozano-Puerto, Maria Albertuz-Crespo, Isaac Lopez-Machado, Lidia Gil-Martinez, Juan Jose Ariza-Romero, Alba Maroto-Tello, Alberto Baos-Arjona, Jose Gutierrez-Fernandez, A Shams, A Mortazavi, K Khosravi-Darani, M Bahmaei, S Fatemeh Seyed Reihani, A Dutt Tripathy, E Atta, N Mohamed, A Abdelgawad, Z Selamoglu, M Sevindik, C Bal, B Ozaltun, Sen, A Pasdaran, S Kumar, A Bathla, A Rani, S Singh, P Gautam, N Chandra Sahi, H Chandra Joshi, V Kumar, W Yehye, N Rahman, A Ariffin, S Hamid, A Alhadi, F Kadir, M Yaeghoobi, Y Murakami, A Kawata, T Katayama, S Fujisawa, G Jayaprakasha, B Girennavar, B Patil, I Choi, W Park, Y Kim, G Martnez-Fernndez, L Abecia, A Martn-Garca, E Ramos-Morales, S Denman, C Newbold, E Molina-Alcaide, D Yez-Ruiz, P Abad, Natalia Arroyo-Manzanares, Lidia Gil, Ana Garca-Campaa, P Abad, N Arroyo-Manzanares, J Ariza, A Baos, A Garca-Campaa, Amin Galavi
Abstract
The antioxidant activity of S-alkyl-4-aminobenzene-, S-allyl-4-aminobenzene- and 4-acetylaminobenzenethiosulfonates were determined by DPPH assay in experiments in vitro to establish the relationship between their structure and activity. Among the test compounds, the highest rates of these activities were found for S-allyl-4-aminobenzenethiosulfonate (ATS), S-ethyl-4-aminobenzene thiosulfonate (ETS), and S-allyl-acetyl-aminobenzenesulfonate (AATS). These compounds were studied in experiments in vivo. The processes of lipid peroxidation (LPO) and the state of the antioxidant system in the blood of rats under the influence of thiosulfonates were studied. The use of thiosulfonate additive to feed at a concentration of 100 mg/kg body weight of animals for 21 days did not cause pathological changes in rats' blood and positively influenced antioxidant blood levels.