Artesunate inhibits epithelial-mesenchymal transition in non-small-cell lung cancer (NSCLC) cells by down-regulating the expression of <i>BTBD7</i>
Jingsi Wang, Mingjuan Wang, Xiao Lu, Jiao Zhang, Quanxing Liu, Dong Zhou, Jigang Dai, Hong Zheng
Abstract
overexpression plasmid. Our study demonstrated the potent anti-migratory activity of ART, thereby presenting it as a new candidate for clinical therapy in NSCLC.
Topics & Concepts
VimentinCancer researchEpithelial–mesenchymal transitionDownregulation and upregulationCell migrationA549 cellTransfectionArtesunateLung cancerBiologyCell cultureChemistryMedicineCancerImmunologyPathologyInternal medicineMetastasisImmunohistochemistryPlasmodium falciparumGeneGeneticsBiochemistryMalariaCancer-related Molecular PathwaysNeuroblastoma Research and TreatmentsCancer Mechanisms and Therapy