Inhibition of Th17 cells by donepezil ameliorates experimental lung fibrosis and pulmonary hypertension
Yuan Guo, Ziyu He, Zhu Chen, Fengling Chen, Chengming Wang, Wanlu Zhou, Jie Liu, Hao Liu, Ruizheng Shi
Abstract
DON can alleviate lung fibrosis and PH in an experimental mouse model. It inhibited pro-inflammatory Th17 cell differentiation, which is dependent on a cholinergic receptor pathway, thereby regulating fibroblast activation.
Topics & Concepts
DonepezilPulmonary hypertensionCholinesterasePulmonary fibrosisLungMedicinePharmacologyFibrosisInternal medicineCardiologyDementiaDiseasePhosphodiesterase function and regulationPharmacological Receptor Mechanisms and EffectsAdenosine and Purinergic Signaling