mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote KrasG12D-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis
Yamin Zhao, Benjamin Schoeps, Dianbo Yao, Zhiheng Zhang, Kathleen Schuck, Vivien Tissen, Carsten Jäger, Anna Melissa Schlitter, Rob van der Kammen, Christina Ludwig, Jan DʼHaese, Susanne Raulefs, Nadja Maeritz, Shanshan Shen, Xiaoping Zou, Achim Krüger, Jörg Kleeff, Christoph Michalski, Helmut Frieß, Metello Innocenti, Bo Kong
Topics & Concepts
mTORC1mTORC2MetaplasiaCarcinogenesisCancer researchPancreasPathologyMedicineBiologyCell biologyInternal medicineCancerSignal transductionPI3K/AKT/mTOR pathwayPI3K/AKT/mTOR signaling in cancerPancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling