Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy
James Michael Brimson, Mani Iyer Prasanth, Dicson Sheeja Malar, Sirikalaya Brimson, Premrutai Thitilertdecha, Tewin Tencomnao
Abstract
: Drugs with sigma affinity potentially offer protection against the most severe symptoms of SARS-CoV-2 via interactions with the sigma-1 receptor. Agonists of the sigma-1 receptor may provide protection of the mitochondria, activate mitophagy to remove damaged and leaking mitochondria, prevent ER stress, manage calcium ion transport, and induce autophagy to prevent cell death in response to infection.
Topics & Concepts
AutophagySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Sigma-1 receptorCoronavirus disease 2019 (COVID-19)VirologyMedicine2019-20 coronavirus outbreakBiologySars virusReceptorIntensive care medicineImmunologyDiseaseInternal medicineOutbreakGeneticsApoptosisInfectious disease (medical specialty)AgonistPharmacological Receptor Mechanisms and EffectsLong-Term Effects of COVID-19Vagus Nerve Stimulation Research