Obesity-induced reduced expression of the lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation
Fang Fang Zhang, Yu Hong Liu, Dan Wei Wang, Ting Sheng Liu, Yue Yang, Jia Guo, Yi Pan, Yan Feng Zhang, Hong Du, Ling Li, 良樹 鷹津
Topics & Concepts
Downregulation and upregulationIsletTranscription factorBiologyRNA methylationBeta cellGene knockdownGlucose homeostasisDNA methylationInsulinLong non-coding RNAInternal medicineEpigeneticsEndocrinologyChromatin immunoprecipitationMethylationCell biologyInsulin resistanceGene expressionMethyltransferaseMedicineGenePromoterGeneticsCancer-related molecular mechanisms researchPancreatic function and diabetesLipid metabolism and disorders