IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease
Gengfu Dong, Chatick Moparthy, Trace Thome, Kyoungrae Kim, Yue Feng, Terence E. Ryan
Abstract
Lower-extremity peripheral arterial disease (PAD) has increased in prevalence, yet therapeutic development has remained stagnant. Skeletal muscle health and function has been strongly linked to quality of life and medical outcomes in patients with PAD. Using a rodent model of PAD, this study demonstrates that treatment of the ischemic limb with insulin-like growth factor (IGF)-1 significantly increases muscle size and strength without improving limb hemodynamics. Interestingly, the effect size of IGF1 therapy was larger in female mice than in male mice, highlighting the need to carefully examine sex-dependent effects in experimental PAD therapies.
Topics & Concepts
PeripheralArterial diseaseMedicineDiseaseSkeletal muscleInternal medicineCardiologyMedical therapyHemodynamicsPhysical medicine and rehabilitationVascular diseasePeripheral Artery Disease ManagementAngiogenesis and VEGF in CancerLymphatic System and Diseases