Synthesis of Some Novel Nanosized Chelates of Anchoring Bisazo Dye 5-[5-(4,6-Dioxo-2-thioxo-hexahydro-pyrimidin-5-ylazo)-naphthalen-1-ylazo]-2-mercapto-1<i>H</i>-pyrimidine-4,6-dione and Their Applications as Antioxidant and Antitumor Agents
Fatma I. Abouzayed, Saeyda A. Abouel‐Enein, Amira M. Hammad
Abstract
nanooxide showed remarkable activity against the HepG-2 cell line rather than its precursor Fe(III) complex. Co(II) had a higher antioxidant activity than the other investigated complexes. In both activities, the Cu(II) complex did not show any activity. Molecular modeling and some theoretical studies were validated, and the experimental results were interpreted.
Topics & Concepts
PyrimidineChelationAnchoringChemistryCombinatorial chemistryStereochemistryOrganic chemistryPsychologyCognitive scienceSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsMulticomponent Synthesis of Heterocycles