Graph Convolutional Auto-Encoders for Predicting Novel lncRNA-Disease Associations
Ana B. O. V. Silva, Eduardo J. Spinosa
Abstract
LncRNAs are intermediate molecules that participate in the most diverse biological processes in humans, such as gene expression control and X-chromosome inactivation. Numerous researches have associated lncRNAs with a wide range of diseases, such as breast cancer, leukemia, and many other conditions. In this work, we propose a graph-based method named PANDA. This method treats the prediction of new associations between lncRNAs and diseases as a link prediction problem in a graph. We start by building a heterogeneous graph that contains the known associations between lncRNAs and diseases and additional information such as gene expression levels and symptoms of diseases. We then use a Graph Auto-encoder to learn the representation of the nodes' features and edges, finally applying a Neural Network to predict potentially interesting novel edges. The experimental results indicate that PANDA achieved a 0.976 AUC-ROC, surpassing state-of-the-art methods for the same problem, showing that PANDA could be a promising approach to generate embeddings to predict potentially novel lncRNA-disease associations.