Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis
Colton J. Garelli, Maggi Ahmed Refat, Padma P. Nanaware, Zaida G. Ramirez‐Ortiz, Mehdi Rashighi, Jillian M. Richmond
Abstract
Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal-epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.
Topics & Concepts
AutoantibodyImmunologyMedicineAutoimmunityInfiltration (HVAC)Systemic lupus erythematosusLupus erythematosusCutaneous Lupus ErythematosusAntigenPathologyImmune systemDiseaseAntibodyThermodynamicsPhysicsT-cell and B-cell ImmunologyCell Adhesion Molecules ResearchSystemic Lupus Erythematosus Research