Manganese(<scp>iii</scp>) complexes stabilized with N-heterocyclic carbene ligands for alcohol oxidation catalysis
Giacomo Rigoni, Pamela V. S. Nylund, Martin Albrecht
Abstract
), yet significantly more robust towards deactivation. Secondary and primary alcohols are oxidized, the latter with high selectivity and essentially no overoxidation of the aldehyde product to carboxylic acids unless the reaction time is substantially extended. Mechanistic investigations using Hammett parameters, IR spectroscopy, isotope labelling experiments, and specific substrates and oxidants as probes support the formation of a manganese(V) oxo system as the active species and subsequent turnover-limiting hydrogen atom abstraction.
Topics & Concepts
CarbeneChemistryManganeseCatalysisAlcoholMedicinal chemistryAlcohol oxidationCombinatorial chemistryOrganic chemistryOxidative Organic Chemistry ReactionsAsymmetric Hydrogenation and CatalysisOrganometallic Complex Synthesis and Catalysis