Bedquiline Resistance Mutations: Correlations with Drug Exposures and Impact on the Proteome in M. tuberculosis
Jian Xu, Dongshuo Li, Jinghua Shi, Bin Wang, Fei Ge, Zhenyong Guo, Xiaopan Mu, Eric L. Nuermberger, Yu Lu
Abstract
mutations conferring BDQ resistance in the proteome analysis. In conclusion, exposure to different bedaquiline concentrations resulted in the selection of different mutations. The coexpression of MmpL5 and MmpS5 contributed to drug resistance and upregulated pathogenic proteins in M. tuberculosis, suggesting MmpL5-MmpS5 as a new potential target for antituberculosis drug development. These results warrant further surveillance for the evolution of BDQ resistance during clinical usage.
Topics & Concepts
TuberculosisDrug resistanceProteomeExtensively drug-resistant tuberculosisDrugMycobacterium tuberculosisComputational biologyBiologyMedicineGeneticsMicrobiologyPharmacologyMultiple drug resistancePathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisAntibiotic Resistance in Bacteria