A short course of tofacitinib sustains the immunoregulatory effect of CTLA4-Ig in the presence of inflammatory cytokines and promotes long-term survival of murine cardiac allografts
Marcos Iglesias, Saami Khalifian, Byoung Chol Oh, Yichuan Zhang, Devin Miller, Sarah E. Beck, Gerald Brandacher, Giorgio Raimondi
Topics & Concepts
TofacitinibMedicineImmunologyProinflammatory cytokineCytokineImmunosuppressionBlockadeJanus kinasePharmacologyInflammationCancer researchInternal medicineReceptorRheumatoid arthritisT-cell and B-cell ImmunologyImmune Cell Function and InteractionCytokine Signaling Pathways and Interactions