Fisetin regulates gut microbiota to decrease CCR9<sup>+</sup>/CXCR3<sup>+</sup>/CD4<sup>+</sup> T-lymphocyte count and IL-12 secretion to alleviate premature ovarian failure in mice.
Jiajia Lin, Xiaoli Nie, Ying Xiong, Zhangbin Gong, Jiulin Chen, Chuan Chen, Yongyi Huang, Te Liu
Abstract
T-lymphocyte count and IL-12 secretion to regulate the ovarian microenvironment and reduce inflammation, thus exerting therapeutic effects against POF.
Topics & Concepts
FisetinAkkermansiaBiologyLachnospiraceaeGut floraImmunologyAndrologyEndocrinologyBacteriaMedicineLactobacillusFirmicutesGeneticsBiochemistryFlavonoidAntioxidant16S ribosomal RNAGut microbiota and healthTryptophan and brain disordersGenetics, Aging, and Longevity in Model Organisms