Positron Emission Tomography Imaging of Poly–(Adenosine Diphosphate–Ribose) Polymerase 1 Expression in Breast Cancer
Elizabeth S. McDonald, Robert K. Doot, Austin R. Pantel, Michael D. Farwell, Robert H. Mach, Kara N. Maxwell, David A. Mankoff
Abstract
This nonrandomized clinical trial tested [18F]FluorThanatrace as a method for measuring regional poly–(adenosine diphosphate–ribose) polymerase 1 expression in breast cancer and as a potential functional biomarker for breast cancer poly–(adenosine diphosphate–ribose) polymerase inhibitor response.
Topics & Concepts
Poly ADP ribose polymeraseMedicineBreast cancerPolymerasePositron emission tomographyAdenosineAdenosine diphosphatePARP inhibitorCancer researchCancerEnzymeNuclear medicineInternal medicineBiochemistryBiologyPlatelet aggregationPlateletPARP inhibition in cancer therapyDNA Repair MechanismsCytomegalovirus and herpesvirus research