Identification of immunological subtypes of hepatocellular carcinoma with expression profiling of immune-modulating genes
Di Cao, Meng‐Ke Chen, Qingfeng Zhang, Yu-Feng Zhou, Mei‐Yin Zhang, Shi‐Juan Mai, Yaojun Zhang, Minshan Chen, Xiaoxing Li, Hui‐Yun Wang
Abstract
have the worst survival. The 4 immune subtypes were validated in another 72 HCC patients obtained from South China. In conclusion, our findings suggest that HCC patient prognosis is associated with immunophenotypes by T cell infiltration (CD8 expression) and the expression of the adaptive immune resistance gene (B7-H3 or CD47), and this immune classification system will facilitate HCC patient selection for ICI immunotherapy.
Topics & Concepts
Immune systemImmunotherapyHepatocellular carcinomaHCCSImmune checkpointCancer researchCD8Tumor microenvironmentImmunologyBiologyMedicineCancer Immunotherapy and BiomarkersPhagocytosis and Immune RegulationImmunotherapy and Immune Responses