Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy
Andrew M. Thompson, P. D. T. O’Connor, Andrew J. Marshall, Amanda Fortes Francisco, John M. Kelly, Jennifer Riley, Kevin D. Read, Catherine Perez, Scott Cornwall, Richard C. Thompson, Martine Keenan, Karen L. White, Susan A. Charman, Bilal Zulfiqar, Melissa L. Sykes, Vicky M. Avery, Eric Chatelain, William A. Denny
Topics & Concepts
Chagas diseaseParasitemiaIn vivoBenznidazoleTrypanosoma cruziTrypanosoma bruceiPharmacologyTrypanocidal agentChemistryIn vitroDrugDosingDrug developmentMalariaBiologyImmunologyParasite hostingBiochemistryPlasmodium falciparumBiotechnologyWorld Wide WebGeneComputer scienceTrypanosoma species research and implicationsResearch on Leishmaniasis StudiesSynthesis and Biological Evaluation