Investigation of the <i>in vitro</i> anticancer potential of bis(imino)acenaphthene–N-heterocyclic carbene transition metal complexes revealed TrxR inhibition and triggering of immunogenic cell death (ICD) for allyl palladates
Chiara Donati, Ishfaq Ibni Hashim, Nestor Bracho Pozsoni, Laurens Bourda, Kristof Van Hecke, Catherine S. J. Cazin, Fabiano Visentin, Steven P. Nolan, Valentina Gandin, Thomas Scattolin
Abstract
(allyl)] 2a showed excellent TrxR inhibition, reducing activity by 67% and surpassing auranofin. This inhibition strongly correlates with ICD induction, as evidenced by enhanced DAMP marker expression, including superior ATP and HMGB1 release compared to doxorubicin. These findings establish allyl palladates as a novel class of ICD inducers with dual anticancer activity and immune activation potential.
Topics & Concepts
AcenaphtheneCarbeneChemistryIn vitroProgrammed cell deathTransition metalBiochemistryApoptosisPhotochemistryCatalysisAnthraceneClick Chemistry and ApplicationsSynthesis and Biological EvaluationSynthesis and Characterization of Heterocyclic Compounds