Stereochemistry and Recent Applications of Axially Chiral Organic Molecules
Michele Mancinelli, Giorgio Bencivenni, Daniel Pecorari, Andrea Mazzanti
Abstract
This minireview covers the literature of the last decade related to the stereochemistry of axially chiral molecules. The first section reviews the use of dynamic NMR and dynamic HPLC for the ranking of the steric size of common organic moieties. The second and third sections describe the recent advances in the preparation of new atropisomeric scaffolds, and in the asymmetric synthesis of stereogenic axes by means of atroposelective organocatalysis.
Topics & Concepts
ChemistryStereocenterSteric effectsAtropisomerOrganocatalysisAxial symmetryMoleculeEnantioselective synthesisOrganic moleculesStereochemistryAxial chiralityChiral column chromatographyComputational chemistryCombinatorial chemistryOrganic chemistryHigh-performance liquid chromatographyCatalysisEngineeringStructural engineeringAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis