Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer
Chao Wang, Min Shi, Jun Ji, Qu Cai, Qianfu Zhao, Jinling Jiang, Jing Liu, Huan Zhang, Zhenggang Zhu, Jun Zhang
Abstract
assessments, our results revealed that SCD1 exhibited the ability to promote tumor growth, migration and anti-ferroptosis of gastric cancer. The underlying mechanism might involve the alteration of cancer stemness and modulation of cell cycle-related proteins. Moreover, based on our findings, high expression of SCD1 might predict poor prognosis in gastric cancer patients. Our study provided new insights into the potential of SCD1 as a biomarker as well as a therapeutic target in the treatment of gastric cancer.
Topics & Concepts
CancerCancer researchCancer cellBiologyInternal medicineOncologyMedicineCancer, Lipids, and MetabolismFerroptosis and cancer prognosisCholangiocarcinoma and Gallbladder Cancer Studies