Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution and computational modelling
David A. Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia‐Borràs, K. N. Houk, Rudi Fasan
Topics & Concepts
ChemistryBiocatalysisIntramolecular forceDrug discoveryCyclopropanationCombinatorial chemistryRational designBenzothiopheneBiochemical engineeringStereochemistryNanotechnologyCatalysisOrganic chemistryReaction mechanismEngineeringThiopheneMaterials scienceBiochemistryCyclopropane Reaction MechanismsEnzyme Catalysis and ImmobilizationCatalysis for Biomass Conversion