Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies
Enrique Martín‐Gayo, Ce Gao, Hsiao Rong Chen, Zhengyu Ouyang, Dhohyung Kim, Kellie E. Kolb, Alex K. Shalek, Bruce D. Walker, Mathias Lichterfeld, Xu G. Yu
Abstract
T cells. Correspondingly, monocytes from this neutralizer controller subgroup upregulate genes encoding for chemotaxis and inflammation, and they secrete high levels of IL-12 in response to TLR stimulation. Our results suggest the existence of multi-compartment immune networks between mDCs, Tfh, and monocytes that may facilitate the development of bnAbs in a subgroup of HIV-1 controllers.
Topics & Concepts
ViremiaImmune systemAntibodyImmunologyBiologyInflammationVirologyHIV Research and TreatmentImmune Cell Function and InteractionT-cell and B-cell Immunology