Gut-Spleen Axis: Microbiota via Vascular and Immune Pathways Improve Busulfan-Induced Spleen Disruption
Hanhan Fang, Xiaohui Feng, Tao Xu, Ruqing Zhong, Dongxin Lu, Hongfu Zhang, Wei Shen, Yong Zhao, Liang Chen, Junjie Wang
Abstract
Alginate oligosaccharide (AOS)-improved gut microbiota (A10-FMT) can rescue busulfan disrupted spleen vasculature. A10-FMT improved the cell proliferation rate, endothelial progenitor cell capability, and cell junction molecules to increase vasculature formation in the spleen. This reestablishment restored spleen function by improving spleen immune cells and iron metabolism. These findings are useful for the treatment of spleen vasculature-related diseases.
Topics & Concepts
SpleenImmune systemProgenitor cellBiologyImmunologyStem cellCancer researchCell biologyGut microbiota and healthClostridium difficile and Clostridium perfringens researchDietary Effects on Health