Synthesis and biological (in vitro and in silico) screening of the 4-aryl-fused pyranopyrazole derivatives as enzyme (α-amylase, α-glucosidase, acetylcholinesterase & proteinase) inhibitors with anti-oxidant and cytotoxic activities

Nagwa M. Abdelazeem, Wael M. Aboulthana, Zeinab A. Elshahid, Marwa El‐Hussieny, Aisha A. K. Al‐Ashmawy

2024Journal of Molecular Structure20 citationsDOI

Topics & Concepts

ChemistryBiochemistryAcarboseIn vitroEnzymePharmacologyAmylaseAcetylcholinesteraseMedicineSynthesis and biological activityComputational Drug Discovery MethodsCholinesterase and Neurodegenerative Diseases

Synthesis and biological (in vitro and in silico) screening of the 4-aryl-fused pyranopyrazole derivatives as enzyme (α-amylase, α-glucosidase, acetylcholinesterase &amp; proteinase) inhibitors with anti-oxidant and cytotoxic activities

Topics & Concepts

Synthesis and biological (in vitro and in silico) screening of the 4-aryl-fused pyranopyrazole derivatives as enzyme (α-amylase, α-glucosidase, acetylcholinesterase & proteinase) inhibitors with anti-oxidant and cytotoxic activities