T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria
Victor H. Carpio, Florentin Aussenac, Lucinda Puebla-Clark, Kyle D. Wilson, Alejandro V. Villarino, Alexander L. Dent, Robin Stephens
Abstract
effector and memory cells and were protected from re-infection. Conversely, T-bet KO mice had reduced Th1-bias upon re-infection and prolonged secondary parasitemia. Therefore, each feature of the CD4 T cell population phenotype is uniquely regulated in this persistent infection, and the cytokine profile of memory T cells can be modified to enhance the effectiveness of the secondary response.
Topics & Concepts
BCL6BiologyParasitemiaPopulationImmunologyPlasmodium chabaudiAcquired immune systemSTAT3AntibodyCytokineCell biologyImmune systemB cellMalariaMedicineSignal transductionPlasmodium falciparumGerminal centerEnvironmental healthImmune Cell Function and InteractionT-cell and B-cell ImmunologyMalaria Research and Control