NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival
Katherine T. Best, Anne E. C. Nichols, Emma Knapp, Warren C. Hammert, Constantinos Ketonis, Jennifer H. Jonason, Hani A. Awad, Alayna E. Loiselle
Abstract
-lineage cells in mice increased apoptosis and the deposition of the matrix protein periostin during the late stages of tendon repair, suggesting that persistent NF-κB signaling may facilitate myofibroblast survival and fibrotic progression. Consistent with this, myofibroblasts in human tendon scar samples displayed enhanced prosurvival signaling compared to control tissue. Together, these data suggest that NF-κB may contribute to fibrotic tendon healing through both inflammation-dependent and inflammation-independent functions, such as NF-κB-mediated cell survival.
Topics & Concepts
MyofibroblastCell biologyWound healingCancer researchTendonChemistryBiologyMedicineFibrosisImmunologyAnatomyPathologyTendon Structure and TreatmentLaser Applications in Dentistry and MedicineAdvanced Fiber Laser Technologies