Nickel-Catalyzed Addition of C–C Bonds of Amides to Strained Alkenes: The 1,2-Carboaminocarbonylation Reaction
Yuri Ito, Syun Nakatani, Ryota Shiraki, Takuya Kodama, Mamoru Tobisu
Abstract
C(aryl)-C(═O) bonds of aryl amides can be activated and added across alkenes with the aid of a nickel catalyst. This 1,2-carboaminocarbonylation reaction enables the dicarbofunctionalization of alkenes with an atom economy of 100%.
Topics & Concepts
ChemistryCatalysisNickelArylAtom economyAtom (system on chip)Medicinal chemistryOrganic chemistryAlkylComputer scienceEmbedded systemCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods