Viral Infections: Negative Regulators of Apoptosis and Oncogenic Factors
Alexey V. Zamaraev, Boris Zhivotovsky, Gelina S. Kopeina
Abstract
The disruption of apoptotic cell death process is closely associated with the etiology of various diseases, including cancer. Permanent viral infections can cause different types of cancers. Oncogenic viruses manipulate both external and internal apoptosis pathways, and inhibit the activity of proapoptotic proteins and signaling pathways, which facilitates carcinogenesis. Ineffective immune surveillance or immune response suppression can induce uncontrolled virus propagation and host cell proliferation. In this review, we discuss current data that provide insights into mechanisms of apoptotic death suppression by viruses and their role in oncogenesis.
Topics & Concepts
CarcinogenesisApoptosisImmune systemBiologyProgrammed cell deathSignal transductionImmune surveillanceVirusCancerImmunologyCancer researchCell biologyGeneticsVirus-based gene therapy researchAnimal Virus Infections StudiesHepatitis B Virus Studies