Expanding The Arsenal Against Pulmonary Diseases Using Surface-Functionalized Polymeric Micelles: Breakthroughs and Bottlenecks
Rubiya Khursheed, Keshav Raj Paudel, Monica Gulati, Sukriti Vishwas, Niraj Kumar Jha, Philip M. Hansbro, Brian G. Oliver, Kamal Dua, Sachin Kumar Singh
Abstract
Pulmonary diseases such as lung cancer, asthma and tuberculosis have remained one of the common challenges globally. Polymeric micelles (PMs) have emerged as an effective technique for achieving targeted drug delivery for a local as well as a systemic effect. These PMs encapsulate and protect hydrophobic drugs, increase pulmonary targeting, decrease side effects and enhance drug efficacy through the inhalation route. In the current review, emphasis has been placed on the different barriers encountered by the drugs given via the pulmonary route and the mechanism of PMs in achieving drug targeting. The applications of PMs in different pulmonary diseases have also been discussed in detail.