Immune Response Gene-1 [IRG1]/itaconate protect against multi-organ injury via inhibiting gasdermin D-mediated pyroptosis and inflammatory response
Wenchang Yang, Yaxin Wang, Yongzhou Huang, Tao Wang, Chengguo Li, Peng Zhang, Weizhen Liu, Yuping Yin, Ruidong Li, Kaixiong Tao
Topics & Concepts
PyroptosisSepsisLipopolysaccharideImmune systemMedicineLungApoptosisTumor necrosis factor alphaIn vivoOrgan dysfunctionInflammationLiver injuryImmunologyPharmacologyBiologyInternal medicineBiochemistryInflammasomeBiotechnologyInflammasome and immune disordersSepsis Diagnosis and TreatmentImmune cells in cancer