Paclitaxel-loaded cubosome lipid nanocarriers stabilised with pH and hydrogen peroxide-responsive steric stabilisers as drug delivery vehicles
Xudong Cai, Bo Fan, San H. Thang, Calum J. Drummond, Nhiem Tran, Jiali Zhai
Abstract
cytotoxicity and cell uptake studies further investigated the cellular interactions of these cubosomes. It was found that cubosomes containing PTX had more toxic effects than the control free PTX sample. Compared to cubosomes stabilised by the non-responsive block copolymer Pluronic® F127, the ABC-stabilised cubosomes also had higher cell internalisation efficiency demonstrated by the cytoplasmic fluorescence intensities using confocal microscopy. These results demonstrated that ABCs containing responsive moieties can stabilise lipid cubosomes and enhance controlled release of poorly soluble chemotherapeutics and cellular uptake.
Topics & Concepts
NanocarriersPaclitaxelHydrogen peroxideDrug deliverySteric effectsChemistryDrugNanotechnologyCombinatorial chemistryMaterials sciencePharmacologyOrganic chemistryMedicineChemotherapySurgeryLipid Membrane Structure and BehaviorNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery