The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development
Sannula Kesavardhana, R. K. Subbarao Malireddi, Amanda R. Burton, Shaina N. Porter, Peter Vogel, Shondra M. Pruett‐Miller, Thirumala‐Devi Kanneganti
Abstract
mice from perinatal lethality caused by ZBP1-driven cell death and inflammation. Our findings identify the essential role of the Zα2 domain of ZBP1 in several physiological functions and establish a link between Z-RNA sensing via the Zα2 domain and promotion of influenza-induced PANoptosis and perinatal lethality.
Topics & Concepts
LethalityDomain (mathematical analysis)BiologyCell biologyVirologyGeneticsChemistryMathematical analysisMathematicsUbiquitin and proteasome pathwaysRNA modifications and cancerinterferon and immune responses