Discovery of ellagic acid as a competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) for cancer treatment: In vitro and in silico study
Chunhui Ma, Jifeng Zhao, Xuguang Zhang, Chuanhua Ding, Huihui Hao, Yinghui Ji, Lipeng Li, Zhentao Guo, Wen‐Shan Liu
Topics & Concepts
Ellagic acidChemistryBiochemistryIC50Docking (animal)PhosphorylationMolecular biologyPharmacologyIn vitroBiologyAntioxidantPolyphenolMedicineNursingProtein Tyrosine PhosphatasesPI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling